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Document the vial change in your protocol notes, as switching mid-study introduces a variable that may affect reproducibility

Therefore, it is known that, in some cases, where the liver is unable to perform effectively (whether it be from clinical disease, medications, alcohol abuse, protein digestion issues such as leaky gut, lack of stomach acid (PPIs), NFLS or gluten intolerance), the build-up of toxins and the use of amino acids for detoxification could suffer, as the availability of amino acids for its functionality is challenged

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Mouse studies show NR increases hepatic NAD+ better than nicotinic acid and nicotinamide [5]